Special warnings about Comtan
Use of Comtan can cause low blood pressure, with symptoms such as dizziness, nausea, fainting, and sweating. Be careful when standing up after you have been sitting or lying down. See how Comtan affects you before you drive a car or operate machinery.
Nausea and diarrhea are especially common side effects of Comtan, developing in more than 10 percent of those taking it. In rare cases, the problem is severe. Comtan may also cause hallucinations, and occasionally triggers new movement disorders. In about 10 percent of those taking it, it has the harmless side effect of turning the urine a brownish-orange color.
An abrupt discontinuation of Comtan can cause a reappearance of Parkinson's symptoms. If a decision is made to discontinue the drug, it should be withdrawn slowly, under a doctor's supervision.
This drug is not intended for use in children.
Possible food and drug interactions when taking Comtan
If Comtan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Comtan with the following:
Antidepressant drugs classified as MAO inhibitors, including Nardil and Parnate (Comtan can be used with a special type of MAO inhibitor called selegiline, which is used for treating Parkinson's disease)
Certain antibiotics, including ampicillin and erythromycin
Special information if you are pregnant or breastfeeding
The possibility of damage to a developing baby has not been ruled out. Tell your physician immediately if you are pregnant or plan to become pregnant. Comtan may appear in breast milk. It should be used with caution if you are nursing your baby.
Recommended dosage for Comtan
The recommended dose is one 200-milligram tablet with each dose of Sinemet, up to a maximum of 8 doses per day. If you were taking more than 800 milligrams of levodopa per day before starting Comtan, you will probably need a reduction in your levodopa dose once you begin taking the drug.
Little is known about the result of Comtan overdose. However, the results could be serious, so if you suspect an overdose, seek medical attention immediately.